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Controlled destabilization of a liposomal drug delivery system enhances mitoxantrone antitumor activity

✍ Scribed by Madden, Thomas D.; Adlakha-Hutcheon, Gitanjali; Bally, Marcel B.; Shew, Clifford R.


Book ID
109484201
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
452 KB
Volume
17
Category
Article
ISSN
1087-0156

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Secretory phospholipase A 2 (sPLA 2 ) belongs to a family of small interfacially active enzymes that catalyze the hydrolysis of phospholipids, yielding lysolipids and fatty acids. sPLA 2 is found in snake and bee venom and also in inflammatory and cancerous tissue. It is mainly active on organized l