Controlled crystallization of hydrocortisone by ultrasonic irradiation

✍ Scribed by Robert M. Cohn; Donald M. Skauen

• Book ID: 102913290
• Publisher: John Wiley and Sons
• Year: 1964
• Tongue: English
• Weight: 597 KB
• Volume: 53
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600530912

✦ Synopsis

A procedure has been developed to prepare low micron panicles of hydrocortisone by direct crystallization of suitably pre ared supersaturated solutions in an ultrasonic field. The solvent system employed &r the preparation of the saturated solutions was observed to be a factor in controlling particle size distribution, while the e&cts ~~~