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Control-Relevant Modeling of the Antitumor Effects of 9-Nitrocamptothecin in SCID Mice Bearing HT29 Human Colon Xenografts

✍ Scribed by John M. Harrold; Julie L. Eiseman; Erin Joseph; Sandra Strychor; William C. Zamboni; Robert S. Parker


Publisher
Springer
Year
2005
Tongue
English
Weight
401 KB
Volume
32
Category
Article
ISSN
1573-8744

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## Abstract The antitumor activity of a colon‐specific __N__‐(2‐hydroxypropyl)methacrylamide (HPMA) copolymer – 9‐aminocamptothecin (9‐AC) conjugate (P‐9‐AC) was assessed in orthotopic and subcutaneous animal (HT29 xenograft) tumor models. P‐9‐AC treatment of mice bearing orthotopic colon tumors, w