Antitumor Efficacy of Colon-Specific HPM
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Song-Qi Gao; Yongen Sun; Pavla Kopečková; C. Matthew Peterson; Jindřich Kopeček
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Article
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2009
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John Wiley and Sons
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English
⚖ 525 KB
## Abstract The antitumor activity of a colon‐specific __N__‐(2‐hydroxypropyl)methacrylamide (HPMA) copolymer – 9‐aminocamptothecin (9‐AC) conjugate (P‐9‐AC) was assessed in orthotopic and subcutaneous animal (HT29 xenograft) tumor models. P‐9‐AC treatment of mice bearing orthotopic colon tumors, w