Control over the Localization of Positive Charge in DNA: The Effect on Duplex DNA and RNA Stability
โ Scribed by Heystek, Lauren E.; Zhou, Hui-qiang; Dande, Prasad; Gold, Barry
- Book ID
- 127119897
- Publisher
- American Chemical Society
- Year
- 1998
- Tongue
- English
- Weight
- 48 KB
- Volume
- 120
- Category
- Article
- ISSN
- 0002-7863
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๐ SIMILAR VOLUMES
Dedicated to Professor Dieter Seebach on the occasion of his 65th birthday Oligonucleotides containing a phenanthrene-derived, non-nucleosidic building block with flexible linkers were synthesized. The effect of the phenanthrene moiety on duplex stability at different positions was investigated. Pla
## Abstract Phenanthreneโ1,2โdimethanol was incorporated into oligodeoxynucleotides __via__ formation of phosphodiester bonds (__cf. Schemeโ 1__). If placed at internal positions in a DNA duplex, a strong reduction of duplex stability is observed (__Tableโ 1__). Terminal attachment of stretches of ph