Control of the microsomal mixed-function oxidase byOx2andOx5genes in houseflies

✍ Scribed by M. A. Q. Khan; R. I. Morimoto; J. T. Bederka; J. M. Runnels

• Publisher: Springer
• Year: 1973
• Tongue: English
• Weight: 467 KB
• Volume: 10
• Category: Article
• ISSN: 0006-2928
• DOI: 10.1007/bf00485702

✦ Synopsis

The microsomal mixed-function oxidase (MFO) in houseflies is controlled by two semidominant genes, Ox z and Ox s, situated on chromosomes 2 and 5, respectively. MFO controlled by these genes has almost similar affinity toward cyclodiene epoxidation, but only the one controlled by Ox 5 can degrade DDT. A strain, YFc, homozygousfor both oxidase genes shows twice as much MFO activity toward aIdrin as either of the parent homozygotes, Fc or Y, but only as much activity toward DDT as the parent strain Fc. These Ox 2 and Ox 5 genes in the YFc strain maintain their identity with regard to DDT in their hybrids with a susceptible homozygous strain recessive for the two oxidases as seen by segregation in the test-croys progenies. The Ox 2 gene is situated at 32 units from the Deh and car genes, 40 units from stw, and about 69 units from Mk. The Ox s gene is situated at 40 units from the ocra gene and 82 units from apt on chromosome 5.