✦ LIBER ✦

Control of stem cell proliferation: A density-dependent commitment model

✍ Scribed by John Prothero

Publisher: Elsevier Science
Year: 1980
Tongue: English
Weight: 535 KB
Volume: 84
Category: Article
ISSN: 0022-5193
DOI: 10.1016/s0022-5193(80)80030-0

No coin nor oath required. For personal study only.

✦ Synopsis

A developmental model for the control of stem cell proliferation is presented. The model seeks to account for the production of both static and self-renewing tissues. It is assumed that in both cases the probability of stem cell commitment is a function of cell number or cell density. In the static tissues the commitment process is such that the supply of stem cells comes to be exhausted. In the self-renewing tissues the probability of commitment is homeostatically regulated at one half. Implicit in the model is a potential mechanism to account for the (species-specific) upper limit to animal size.

📜 SIMILAR VOLUMES

Computer model of hemopoietic stem cell

Computer model of hemopoietic stem cell population testing a possible role of DNA synthesizing cells in proliferation control

✍ Nečas, E. ;Hauser, F. ;Neuwirt, J. 📂 Article 📅 1980 🏛 Springer-Verlag ⚖ 626 KB

A model for density-dependent growth of

A model for density-dependent growth of anchorage-dependent mammalian cells

✍ Kelly K. Frame; Wei-Shou Hu 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 375 KB

Difluoromethylornithine stimulates early

Difluoromethylornithine stimulates early cardiac commitment of mesenchymal stem cells in a model of mixed culture with cardiomyocytes

✍ Claudio Muscari; Francesca Bonafé; Marco Carboni; Marco Govoni; Ivana Stanic; Ch 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 157 KB

## Abstract The efficiency of in vitro mesenchymal stem cell (MSC) differentiation into the myocardial lineage is generally poor. In order to improve cardiac commitment, bone marrow GFP^+^MSCs obtained from transgenic rats were cultured with adult wild type rat cardiomyocytes for 5 days in the pres

A stochastic model of self-renewal and c

A stochastic model of self-renewal and commitment to differentiation of the primitive hemopoietic stem cells in culture

✍ Tatsutoshi Nakahata; Alan J. Gross; Makio Ogawa 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 476 KB

## Abstract We recently identified a murine hemopoietic stem cell colony which consists of undifferentiated (blast) cells and appears to be more primitive than CFU‐GEMM in the stem cell hierarchy. The progenitors for the colony which we termed “stem cell colony” possess an extensive self‐renewal ca

FK506 and cyclosporin A inhibit stem cel

FK506 and cyclosporin A inhibit stem cell factor-dependent cell proliferation/survival, while inducing upregulation of c-kit expression in cells of the mast cell line MC/9

✍ Fumihiko Ito; N. Toyota; Hiroyuki Sakai; Hidetoshi Takahashi; Hajime Iizuka 📂 Article 📅 1999 🏛 Springer-Verlag 🌐 English ⚖ 215 KB

Clonality and Life Cycles of Intestinal

Clonality and Life Cycles of Intestinal Crypts Explained by a State Dependent Stochastic Model of Epithelial Stem Cell Organization

✍ M. Loeffler; T. Bratke; U. Paulus; Y.Q. Li; C.S. Potten 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 258 KB

The organization and control of stem cells is a key issue in epithelial cell biology. The small intestinal murine crypt is a useful tissue to study such problems since stem cells are known to be located at specific positions at the bottom of the crypt where they are self maintaining. Recent data sug