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Control of RUNX2 isoform expression: The role of promoters and enhancers

✍ Scribed by Michael Stock; Florian Otto

Book ID
102301271
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
206 KB
Volume
95
Category
Article
ISSN
0730-2312

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✦ Synopsis

The three mammalian RUNX genes constitute the family of runt domain transcription factors that are involved in the regulation of a number of developmental processes such as haematopoiesis, osteogenesis and neuronal differentiation. All three genes show a complex temporo-spatial pattern of expression. Since the three proteins are probably mutually interchangeable with regard to function, most of the specificity of each family member seems to be based on a tightly controlled regulation of expression. While RUNX gene expression is driven by two promoters for each gene, the promoter sequence alone does not seem to suffice for a proper expressional control. This review focuses on the available evidence for the existence of such control mechanisms and studies aiming at discovering cis-acting regulatory sequences of the RUNX2 gene.

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## Abstract The P1 and P2 promoters of the __Cbfa1/Runx2__ gene produce Type I and II mRNAs with distinct complex 5′‐untranslated regions, respectively designated UTR1 and UTR2. To evaluate whether the 5′‐UTRs impart different translational efficiencies to the two isoforms, we created SV40 promoter