## Abstract In recent years, an impact of the p53 tumor suppressor protein in the processes of cellular and organismal ageing became evident. First hints were found in model organisms like __Saccharomyces cerevisiae__, __Caenorhabditis elegans__, and __Drosophila melanogaster__ where a clear connec
✦ LIBER ✦
Control of p53 and NF-κB signaling by WIP1 and MIF: Role in cellular senescence and organismal aging
✍ Scribed by Antero Salminen; Kai Kaarniranta
- Book ID
- 113528483
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 229 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0898-6568
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## Abstract We have previously shown that Hg^2+^, Pb^2+^, and Cu^2+^, significantly modulate the expression of NAD(P):quinone oxidoreductase 1 (Nqo1) in Hepa 1c1c7 cells through oxidative stress‐dependent mechanisms. In the current study, we examined the role of redox‐sensitive transcription factor