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Control of nucleic acid and protein synthesis in developing brain, kidney, and heart of the neonatal rat: Effects of α-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase

✍ Scribed by Slotkin, Theodore A. ;Persons, Derek ;Slepetis, Ruta J. ;Taylor, Donald ;Bartolome, Jorge


Book ID
112217424
Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
1006 KB
Volume
30
Category
Article
ISSN
0040-3709

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✍ M. Sparapani; M. Virgili; M. Caprini; F. Facchinetti; E. Ciani; A. Contestabile 📂 Article 📅 1996 🏛 Springer-Verlag 🌐 English ⚖ 895 KB

Pregnant rats were treated for five consecutive days during gestation with s.c. injections of the ornithine decarboxylase (ODC) inhibitor alpha-difluoromethylornithine (DFMO). Treatment beginning at gestational days 13 or 14 was effective in inhibiting ODC and altering polyamine levels, and resulted