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Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts

✍ Scribed by Hyman, Anthony A.; Tournebize, Régis; Popov, Andrei; Kinoshita, Kazuhisa; Ashford, Anthony J.; Rybina, Sonja; Pozniakovsky, Andrei; Mayer, Thomas U.; Walczak, Claire E.; Karsenti, Eric

Book ID: 109827308
Publisher: Nature Publishing Group
Year: 1999
Tongue: English
Weight: 808 KB
Volume: 2
Category: Article
ISSN: 1465-7392
DOI: 10.1038/71330

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## Abstract **Background:** MCM and Cdc45 are required for the initiation and elongation stages of eukaryotic DNA replication. Recent studies show that a purified Mcm4/6/7 complex has DNA helicase activity. However, the biochemical function of the MCM complex and Cdc45 bound to chromatin has not be