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Control of irinotecan-induced diarrhea by octreotide after loperamide failure

โœ Scribed by Vassilios Barbounis, George Koumakis, Michael Vassilomanolakis, Matina Demiri, Anna P. Efremidis

Book ID
113046729
Publisher
Springer-Verlag
Year
2001
Tongue
English
Weight
47 KB
Volume
9
Category
Article
ISSN
0941-4355

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โœ Yuichiro Takeda; Kunihiko Kobayashi; Yoshiko Akiyama; Tomoyuki Soma; Satoko Hand ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 92 KB

It has been reported that 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin (CPT-11) and its active metabolite, 7-ethyl-10-hydroxy-camptothecin (SN-38), have absorption characteristics of weakly basic drugs, suggesting that alkalization of the intestinal lumen might reduce reabsorpt