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Control of inflammatory diseases by pathogens: lipids and the immune system

✍ Scribed by Desiree van der Kleij; Maria Yazdanbakhsh

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
246 KB
Volume
33
Category
Article
ISSN
0014-2980

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✦ Synopsis

Abstract

Inflammatory diseases such as asthma and diabetes are rising in industrialized countries and the modern lifestyle that is associated with lower exposure to microbes has been held responsible for the increasing prevalence of these diseases. Several studies have shown an inverse association between pathogen‐exposure and allergy or autoimmunity. The mechanisms behind such protective effectshave been investigated at the epidemiological, cellular and molecular level and have provided data on the ability of lipids either derived directly from pathogens or up‐regulated as a result of an infection to down‐regulate immune responses and thereby control inflammatory diseases. In this mini‐review, recent findings and new concepts relating to the immunosuppressive effects of endogenous lipids and those encountered upon exposure to bacteria, protozoa and particularly helminths are discussed. The overview focuses on the modulation of interactions between the antigen‐presenting compartment and T cells to start an anti‐inflammatory "program" with potential to regulate disease processes.

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