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Control of hypoxia-induced tumor cell adhesion by cytophilic human catalase

✍ Scribed by Tomoya Yata; Makiya Nishikawa; Chika Nishizaki; Masahide Oku; Hiroya Yurimoto; Yasuyoshi Sakai; Yoshinobu Takakura

Book ID
113630989
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
703 KB
Volume
47
Category
Article
ISSN
0891-5849

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## Abstract The limitation of proliferative potential in human somatic cells imposed by replicative senescence has been proposed as a mechanism of tumor suppression. The E3 ubiquitin ligase Smurf2 is up‐regulated during replicative senescence in response to telomere shortening, and induces senescen