Confluent cultures of human endothelial cells deposit into extracellular matrix (ECM) distinct heparan sulfate proteoglycans (HSPG) which modulate acidic fibroblast growth factor's (aFGF) ability to stimulate human endothelial cell mitogenic capacity. Extracellular matrix 'IS-HSPG were isolated from
Control of Growth Factor Networks by Heparan Sulfate Proteoglycans
β Scribed by Kimberly Forsten-Williams; Chia Lin Chu; Michael Fannon; Jo Ann Buczek-Thomas; Matthew A. Nugent
- Book ID
- 106333843
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 953 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0090-6964
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The effects of cell surface heparan sulfate proteoglycan (HSPG) prepared from log and confluent monolayers of a rat hepatoma cell line on hepatoma cell growth were studied. When HSPG isolated from confluent cells was added exogenously to log phase cells, it was internalized and free heparan sulfate
## Abstract Understanding the process of wound healing will provide valuable insight for the development of new strategies to treat diseases associated with improper regeneration, such as blindness induced by corneal scarring. Heparan sulfate proteoglycans (HSPG) are not normally expressed in the c
Fetal calf serum (FCS) and PMA (phorbol 12-myristate-13-acetate) specifically stimulate the synthesis of heparan sulfate proteoglycan in endothelial cells. Staurosporine and n-butanol, kinase inhibitors, abolish the PMA effect. Forskolin and 8-bromo adenosine 3':5'-cyclic monophosphate, activators o