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Control of granzymes by serpins

โœ Scribed by Kaiserman, D; Bird, P I


Book ID
109841229
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
623 KB
Volume
17
Category
Article
ISSN
1350-9047

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Conditional on perforin-dependent delivery to the nucleus of target cells, the cytolytic granule serine protease granzyme B (GrB) plays a central role in eliciting the nuclear events of apoptosis, as shown by the fact that reducing GrB nuclear entry prevents nuclear apoptosis. Apart from a requireme