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Control of glycolysis in rat liver by glucokinase and phosphofructokinase: influence of glucose concentration

✍ Scribed by Néstor V. Torres; Fátima Mateo; José M. Riol-Cimas; Enrique Meléndez-Hevia

Publisher
Springer
Year
1990
Tongue
English
Weight
381 KB
Volume
93
Category
Article
ISSN
0300-8177

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✦ Synopsis

Control of glucose metabolism in rat liver under different glucose concentrations was studied. Flux Control Coefficients of glucokinase, glucose 6-phosphate isomerase and phosphofructokinase were determined by the 'shortening and enzyme titration' method. Results obtained show that glucose concentration in liver can play an important role in control of liver glycolysis by enhancing the Flux Control Coefficient of phosphofructokinase. Possible physiological significance of this fact is discussed.

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Control analysis of rat liver glycolysis
Control analysis of rat liver glycolysis under different glucose concentrations. The substrate approach and the role of glucokinase
✍ Enrique Meléndez-Hevia; Fátima Mateo; Néstor V. Torres 📂 Article 📅 1992 🏛 Springer 🌐 English ⚖ 652 KB

Control Analysis has been carried out in the first steps of a rat liver glycolytic system. Attention has been focused on the effect of several glucose concentrations on the control, particularly regarding the role of glucokinase. From kinetic studies of the whole metabolic system we have obtained in