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Control of gene expression inXenopus early development

✍ Scribed by Hair, Alan ;Prioleau, Marie-Noëlle ;Vassetzky, Yegor ;Méchali, Marcel

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 204 KB
Volume: 22
Category: Article
ISSN: 0192-253X
DOI: 10.1002/(sici)1520-6408(1998)22:2<122::aid-dvg2>3.0.co;2-8

No coin nor oath required. For personal study only.

✦ Synopsis

We examine the control of gene expression before and through the MBT in Xenopus laevis. The generalized repression of transcription that occurs before the midblastula transition (MBT) is regulated by a dynamic competition between chromatin and transcription complex assembly. Conditions favoring the access of basal factors (TBP) or transactivators can overcome this transcriptional repression. Changes in DNase I hypersensitivity patterns of the chromatin during early development show that it is more accessible to DNase I before the MBT (and by extension to other DNA interacting proteins) than after the MBT. We also show that at the level of genomic domains, organization of the chromatin matrix attachment sites is random before MBT. We propose that these three components, chromatin domain structure, DNA accessibility, and the transcription complex-chromatin dynamic competition, combine to regulate transcription in the embryo before and through the MBT.

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