## Abstract Unlike untransformed 3T3 fibroblasts, Simian Virus 40βtransformed 3T3 cells (SV3T3) do not require the presence of exogenous polypeptide mitogens in order to become competent for the initiation of DNA synthesis. As an explanation for this state of perpetual competence, growth activity f
Control of entry of Swiss 3T3 cells into S phase by fibroblast growth factor under serum-free conditions
β Scribed by Gary D. Shipley; Richard G. Ham
- Book ID
- 115891644
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 794 KB
- Volume
- 146
- Category
- Article
- ISSN
- 0014-4827
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π SIMILAR VOLUMES
The effect of inhibition of the cell membrane Na+-K+ pump on the Balbk-3T3 cell growth cycle was studied. Inhibition of the Na+-K+ pump resulted in a dose-dependent reduction of intracellular K+ concentration ({Kf},). However, inhibition of protein synthesis in Gi/G, and of subsequent entry into S p
Fibroblast Growth Factor (FGF) stimulates quiescent Swiss 3T3 cells to initiate DNA synthesis and divide. Cells begin to enter the S-phase after a lag of 13-15 hr, and the rate of initiation of DNA synthesis in the population can be quantified by a first order rate constant, k. A subsaturating conce