The purpose of this study was to determine whether cyclic AMP (cAMP) plays any direct or indirect role in the antiproliferative effect of mouse L-cell interferon in Swiss 3T3 cells. Firstly, we found that interferon did not affect intracellular levels of cAMP in these cells in the absence or the pre
Control of DNA synthesis and mitosis in 3T3 cells by cyclic AMP
β Scribed by Mark C. Willingham; George S. Johnson; Ira Pastan
- Book ID
- 118853399
- Publisher
- Elsevier Science
- Year
- 1972
- Tongue
- English
- Weight
- 299 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0006-291X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The addition of serum to densityβinhibited human fibroblast cultures induced a wave of DNA synthesis, measured as [^3^H] thymidine incorporation into acidβprecipitable material, beginning after 8β12 hr and reaching maximum levels at 16β24 hr. Addition of dibutyrylβ3β² : 5β²βcyclic AMP (DB
The effect of time-controlled exposures to cholera toxin (CT) on intracellular levels of cyclic AMP (CAMP) and on the proliferative response of serumstimulated 3T3 cells was investigated. Continuous exposure to CT caused up to 8-fold raises in cAMP content and inhibited DNA replication by delaying G