✦ LIBER ✦

Control of DNA replication: A new facet of Hox proteins?

✍ Scribed by Benoit Miotto; Yacine Graba

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 157 KB
Volume: 32
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.201000048

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✦ Synopsis

Abstract

Hox proteins are well‐known as developmental transcription factors controlling cell and tissue identity, but recent findings suggest that they are also part of the cell replication machinery. Hox‐mediated control of transcription and replication may ensure coordinated control of cell growth and differentiation, two processes that need to be tightly and precisely coordinated to allow proper organ formation and patterning. In this review we summarize the available data linking Hox proteins to the replication machinery and discuss the developmental and pathological implications of this new facet of Hox protein function.

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