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Control of Culture Environment for Improved Polyethylenimine-Mediated Transient Production of Recombinant Monoclonal Antibodies by CHO Cells

✍ Scribed by Douglas J. Galbraith; Andrew S. Tait; Andrew J. Racher; John R. Birch; David C. James

Book ID: 109387345
Publisher: American Institute of Chemical Engineers
Year: 2006
Tongue: English
Weight: 168 KB
Volume: 22
Category: Article
ISSN: 8756-7938
DOI: 10.1021/bp050339v

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## Abstract In this study we compare the cellular control of recombinant human IgG~4~ monoclonal antibody (Mab) synthesis in different CHO cell lines. Based on comprehensive empirical analyses of mRNA and polypeptide synthetic intermediates we constructed cell line‐specific mathematical models of r