Control of cell fate and differentiation by Sry-related high-mobility-group box (Sox) transcription factors

Ectopic activation of lymphoid high mobi

Ectopic activation of lymphoid high mobility group-box transcription factor TCF-1 and overexpression in colorectal cancer cells

✍ Karin Mayer; Thomas Hieronymus; Jan Castrop; Hans Clevers; Wolfgang G. Ballhause 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 188 KB

Physical interaction between the lymphoid high mobility group (HMG)-box architectural transcription factors TCF/ LEF and b-catenin is associated with translocation of the heteromeric complex to the nucleus and regulation of target gene expression. Since formation of molecular complexes among b-caten