Apolipoprotein (apo) E has been implicated in Alzheimer's disease; however, little is known about the regulation of its secretion in astrocytes. To investigate the eects of pro-in¯ammatory cytokines such as interleukin-1b (IL-1b), tumour necrosis factor-a (TNF-a) and interferon-g (IFN-g) on apoE sec
✦ LIBER ✦
Control of apolipoprotein E secretion by 25-hydroxycholesterol and proinflammatory cytokines in the human astrocytoma cell line CCF-STTG1
✍ Scribed by Y. Gueguen; P. Bertrand; L. Ferrari; A.-M. Batt; G. Siest
- Book ID
- 110308508
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 271 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0742-2091
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Even though it is known that apolipoprotein E (apoE) is deeply involved in major age-related disorders such as atherosclerosis or Alzheimer's disease (AD), the control of cell-specific apoE expression is still poorly understood. We compared the apoE secretion as previously described in astrocytic ce