Control of a human tumour (ewing sarcoma) in mice by a single lethal dose of dimethyl-myleran and bone marrow
✍ Scribed by G. L. Floersheim; J. Torhorst
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- French
- Weight
- 690 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
A Ewing sarcoma grown in immunosuppressed mice was eradicated with a single lethal dose of dimethylmy‐leran (DMM) followed by autologous or syngeneic bone marrow. Sarcomas treated 2 weeks after grafting in a phase of rapid proliferation disappeared and large sarcomas treated after 6 or 10 weeks were reduced to necrotic tissue. A human osteosarcoma also regressed distinctly after this therapy while a human colon carcinoma responded poorly. Sub‐lethal DMM treatment induced complete remissions in only 62% of the mice. Tumours which display sensitivity in this model may be treated clinically with lethal doses of DMM and autologous marrow transplantions.