Contribution of variable domains to the
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Roxana M. Ionescu; Josef Vlasak; Colleen Price; Marc Kirchmeier
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Article
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2008
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John Wiley and Sons
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English
โ 354 KB
Temperature-induced unfolding of three humanized IgG1 monoclonal antibodies and their Fab and Fc fragments was monitored by differential scanning calorimetry at neutral pH. With some exceptions, the thermogram of the intact antibody presents two peaks and the transition with the larger experimental