Contribution à la chimiothérapie de la tuberculose II. Hydrazides des acides alcoyl-2-cinchoniniques

✍ Scribed by Ch. Gansser; P. Rumpf

• Publisher: John Wiley and Sons
• Year: 1953
• Tongue: German
• Weight: 270 KB
• Volume: 36
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.19530360629

✦ Synopsis

Following a new conception with the aim of finding new anti-1 ixlwrcular compounds, some hydrazides and hydrazones of the cinc.honinic acid series substituted in position 2 have been prepared.

The atteinpts to introduce a polar group have been successful only in the cases of isonicotinyloxyethylhydrazide, with a lowering of the biological activity, and of the 2-hexyl-cinchoninic acid hydrazide.

Furthermore, for reasons of analogous electronic configurations with I N H , there have been synthetised some aromatic paranitro hydrazides.

Among those compounds, which have been tested in ritro, only thc hyvdrazides of the 2-hexyl-cinchoninic acid and the paranitrosalicylic acid show some notable antitubercular activity.