Contribution of the Peptide Backbone to the Action of Oxytocin Analogs
β Scribed by Oscar Hechter, Tetsuo Kato, Satoe Hase Nakagawa, Frances Yang and George Flouret
- Book ID
- 123652779
- Publisher
- National Academy of Sciences
- Year
- 1975
- Tongue
- English
- Weight
- 760 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0027-8424
- DOI
- 10.2307/64020
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Pseudo-peptide analogues of the C-terminal tetrapeptide of gastrin, in which a peptide bond has been replaced by a CH2-NH bond, i.e. (tert-butyloxycarbonyl)-L-tryptophyl-psi (CH2-NH)-L-leucyl-L-aspartyl-L-phenylalanine amide (8), (tert-butyloxycarbonyl)-L-tryptophyl-L-leucyl-psi (CH2-NH)-L-aspartyl-
## Abstract In order to investigate the relationship between the primary structure of Orpotrin, a vasoactive peptide previously isolated from the freshwater stingray __Potamotrygon gr. orbignyi__, and its microcirculatory effects, three Orpotrin analogs were synthesized. The analogs have a truncate