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Contribution of the nucleus accumbens to cocaine-induced responses of ventral pallidal neurons

✍ Scribed by Patricia I. Johnson; T. Celeste Napier

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 972 KB
Volume: 22
Category: Article
ISSN: 0887-4476
DOI: 10.1002/(sici)1098-2396(199603)22:3<253::aid-syn8>3.0.co;2-b

No coin nor oath required. For personal study only.

✦ Synopsis

The present study characterized the responses of ventral pallidal (VP) neurons to intravenously (iv) administered cocaine (0.003, 0.01, 0.03, 0.1, 0.3, and 1.0 mgkg) in chloral hydrate-anesthetized rats. Eighty-four percent (16119) of the tested neurons displayed rate changes following cocaine administration. Fifty-three percent responded by increasing firing rate, with an Em of 217 ? 26% of basal activity and an ED50 of 0.07 ? 0.03 mgkg. Neurons that responded with a rate decrease (26%) had an Em of 14.3 2 9.0% of basal control and an ED50 of 0.04 2 0.02 mg/kg. One neuron (5%) displayed a biphasic response pattern. Haloperidol (0.2 mg/kg) attenuated cocaineinduced effects in 90% of the tested neurons. Given the responsiveness of VP neurons to cocaine, the extensive innervation of the VP by the nucleus accumbens (NAC), and the importance of the NAC in regulating cocaine-induced effects, it is likely that NAC activity may affect VP responses to cocaine. To test this possibility, the influence of NAC on cocaine-induced VP activity was evaluated. Unilateral inactivation of the NAC with microinjections of procaine (40 Fgl2 pY2 min) did not alter the proportion of VP neurons responsive to subsequent systemic administration of cocaine (0.1, 1.0 mgkg iv) or the EM for those neurons showing a rate decrease. However, for the population of neurons showing a cocaine-induced rate increase, intra-NAC procaine significantly enhanced Em to 392 ? 74% of control. These data suggest that the ability of VP neurons to respond to iv cocaine is independent of the NAC. However, the magnitude of the cocaineinduced effect appears to be dependent on NAC influences. o 1996 Wiley-Liss, Inc.

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