✦ LIBER ✦

Contribution of P-glycoprotein to efflux of ramosetron, a 5-HT3 receptor antagonist, across the blood-brain barrier

✍ Scribed by Chika Yamamoto; Hideyasu Murakami; Noriko Koyabu; Hitomi Takanaga; Hirotami Matsuo; Takeshi Uchiumi; Michihiko Kuwano; Mikihiko Naito; Takashi Tsuruo; Hisakazu Ohtani; Yasufumi Sawada

Book ID: 111769106
Publisher: Pharmaceutical Press
Year: 2002
Tongue: English
Weight: 248 KB
Volume: 54
Category: Article
ISSN: 2042-7158
DOI: 10.1211/002235702320266208

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Contribution of P-glycoprotein to bunitr

Contribution of P-glycoprotein to bunitrolol efflux across blood–brain barrier

✍ Jo Matsuzaki; Chika Yamamoto; Tetsuo Miyama; Hitomi Takanaga; Hirotami Matsuo; H 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 143 KB 👁 2 views

In this study, we investigated the mechanism of the blood -brain barrier (BBB) transport of bunitrolol (BTL), as a model of i-blocker, in vivo and in vitro. In order to define the contribution of P-glycoprotein (P-gp) to the active efflux of BTL from brain to blood, we examined the in vivo brain dis

Active efflux of the 5-HT1A receptor ago

Active efflux of the 5-HT1A receptor agonist flesinoxan via P-glycoprotein at the blood–brain barrier

✍ Inez C.J van der Sandt; Raquel Smolders; Lobna Nabulsi; Klaas P Zuideveld; Alber 📂 Article 📅 2001 🏛 Elsevier Science 🌐 English ⚖ 244 KB

Lipophilicities of Baclofen Ester Prodru

Lipophilicities of Baclofen Ester Prodrugs Correlate with Affinities to the ATP-Dependent Efflux Pump P-Glycoprotein: Relevance for Their Permeation Across the Blood-Brain Barrier?

✍ Christiane Leisen; Peter Langguth; Bernd Herbert; Cornelia Dressler; Annette Kog 📂 Article 📅 2003 🏛 Springer US 🌐 English ⚖ 179 KB

Restricted transport of cyclosporin A ac

Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein

✍ Akira Tsuji; Ikumi Tamai; Atsushi Sakata; Yoshiyuki Tenda; Tetsuya Terasaki 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 475 KB

5 In vitro studies of S9788 as a reversi

5 In vitro studies of S9788 as a reversing agent of P-glycoprotein dependent drug transport across the blood-brain barrier

✍ L. Fenart; M. G. Poullain; B. Giroux; R. Cecchelli; M. P. Dehouck 📂 Article 📅 1996 🏛 Springer 🌐 English ⚖ 92 KB

Enhanced cerebral uptake of receptor lig

Enhanced cerebral uptake of receptor ligands by modulation of P-glycoprotein function in the blood–brain barrier

✍ P. Doze; A. Van Waarde; P.H. Elsinga; N.H. Hendrikse;; W. Vaalburg 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 170 KB 👁 2 views

Low cerebral uptake of some therapeutic drugs can be enhanced by modulation of P-glycoprotein (P-gp), an ATP-driven drug efflux pump at the blood-brain barrier (BBB). We investigated the possibility of increasing cerebral uptake of the beta-adrenergic ligands S-1'-[(18)F]-fluorocarazolol (FCAR) and