Contribution of Lysosomes to the Subcellular Distribution of Basic Drugs in the Rat Liver
β Scribed by Junko Ishizaki; Koichi Yokogawa; Masako Hirano; Emi Nakashima; Yoshimichi Sai; Shoji Ohkuma; Tohru Ohshima; Fujio Ichimura
- Book ID
- 110344898
- Publisher
- Springer US
- Year
- 1996
- Tongue
- English
- Weight
- 907 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0724-8741
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Cathepsins B and D, beta-galactosidase, and acid phosphatase activities were found to be decreased in the regenerating rat liver, the reduction being maximal around the peak of hepatocyte mitoses (30 h). To investigate whether these changes could be heterogeneously distributed among hepatic cells, t
## Abstract Differential centrifugation of homogenates of HardingβPassey melanoma demonstrated that aryl sulfatase A and Ξ²βglucuronidase sediment with particles (i.e., lysosomes) distinct from those particles bearing tyrosinase (i.e., melanosomes). The sedimentation curves for the lysosomal enzymes