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CONTRIBUTION OF LATERAL SUBSTITUENTS IN HEPTANE-BISAMMONIUM DERIVATIVES TO THE ALLOSTERIC STABILIZATION OF ANTAGONIST BINDING TO M2-RECEPTORS

✍ Scribed by Markus Staudt; Christian Tränkle; Klaus Mohr; Ulrike Holzgrabe

Book ID
117175375
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
964 KB
Volume
62
Category
Article
ISSN
0024-3205

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Contribution of Lateral Substituents in Symmetrical and Non-symmetrical Heptane-bisammonio Compounds to the Allosteric Stabilization of N-methylscopolamine Binding to Muscarinic M2 Receptors
✍ Markus Staudt; Christian Tränkle; Klaus Mohr; Ulrike Holzgrabe 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 133 KB

## Abstract Allosteric modulators are able to enhance or decrease the equilibrium binding of orthosteric agonists or antagonists. The treatment of Alzheimer's disease and the organophosphorus poisoning can take advantage of the enhancement of the ligand binding. Prerequisite is the formation of ter