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Contribution of Ion Binding Affinity to Ion Selectivity and Permeation in KcsA, a Model Potassium Channel

✍ Scribed by Renart, M. L.; Montoya, E.; Fernández, A. M.; Molina, M. L.; Poveda, J. A.; Encinar, J. A.; Ayala, J. L.; Ferrer-Montiel, A. V.; Gómez, J.; Morales, A.

Book ID
115475724
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
465 KB
Volume
51
Category
Article
ISSN
0006-2960

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Modeling of ion permeation in calcium an
Modeling of ion permeation in calcium and sodium channel selectivity filters
✍ P.S. Raj Ganesh; Baron Chanda; S.K. Gupta; M.K. Mathew; Jayaraman Chandrasekhar 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 193 KB 👁 1 views

## Structure-function studies have shown that it is possible to convert a sodium channel to a calcium-selective channel by a single amino acid substitution in the selectivity filter locus. Ion permeation through the "model selectivity filter" was modeled with a reduced set of functional groups repr