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Contribution of higher risk genes and European admixture to Crohn's disease in African Americans

✍ Scribed by Ming-Hsi Wang; Toshihiko Okazaki; Subra Kugathasan; Judy H. Cho; Kim L. Isaacs; James D. Lewis; Duane T. Smoot; John F. Valentine; Howard A. Kader; Jean G. Ford; Mary L. Harris; Maria Oliva-Hemker; Carmen Cuffari; Michael S. Torbenson; Richard H. Duerr; Mark S. Silverberg; John D. Rioux; Kent D. Taylor; Geoffrey C. Nguyen; Yuqiong Wu; Lisa W. Datta; Stanley Hooker; Themistocles Dassopoulos; Rick A. Kittles; Linda W.H. Kao; Steven R. Brant


Book ID
112101318
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
855 KB
Volume
18
Category
Article
ISSN
1078-0998

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Background: IBD5, IL23R, and ATG16L1 genetic variations are established Crohn's disease (CD) risks alleles. We evaluated these in a population-based case-control study within a cohort to determine their penetrance, population attributable risk, independence, and relationship to other established CD