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Contribution of H3K4 methylation by SET-1A to interleukin-1–induced cyclooxygenase 2 and inducible nitric oxide synthase expression in human osteoarthritis chondrocytes

✍ Scribed by Fatima Ezzahra El Mansouri; Nadir Chabane; Nadia Zayed; Mohit Kapoor; Mohamed Benderdour; Johanne Martel-Pelletier; Jean-Pierre Pelletier; Nicolas Duval; Hassan Fahmi


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
531 KB
Volume
63
Category
Article
ISSN
0004-3591

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## Abstract 4‐hydroxynonenal (HNE), a lipid peroxidation end product, is produced abundantly in osteoarthritic (OA) articular tissues and was recently identified as a potent catabolic factor in OA cartilage. In this study, we provide additional evidence that HNE acts as an inflammatory mediator by