𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Contribution of each complex of the mitochondrial respiratory chain in the generation of the proton-motive force

✍ Scribed by Santiago Garcia-Vallve

Publisher
The American Society for Biochemistry and Molecular Biology
Year
2004
Tongue
English
Weight
77 KB
Volume
32
Category
Article
ISSN
1470-8175

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A new parameter is presented for considering the contribution from each complex of the mitochondrial respiratory chain to the creation of the electrochemical gradient. This parameter is the proton gradient generated in each complex per pair of electrons transported (Ξ”H^+^/2e^βˆ’^) and may be calculated as the sum of the electrons taken up from the N‐side and the electrons released at the P‐side. The Ξ”H^+^/2e^βˆ’^ values take into account all the electrons taken up and released in each complex and differentiate between the contribution from protons that are translocated from the N‐side to the P‐side and the contribution of scalar protons. Using these values, the P/O ratios for the oxidation of NADH and succinate are predicted to be 2.5 and 1.5, respectively.

πŸ“œ SIMILAR VOLUMES

Hepatotoxic effect of cyclosporin A in t
Hepatotoxic effect of cyclosporin A in the mitochondrial respiratory chain
✍ Lilia Cristina De la Cruz RodrΓ­guez; Carmen Rosa Araujo; Sara Emilia Posleman; M πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 489 KB πŸ‘ 1 views

## Abstract Cyclosporin A (CyA), a potent immunosuppressant, was used to determine the hepatotoxic effect in long‐term treatments. Male Wistar rats were used in these experiments. They were given CyA chronically at doses used in patients for 120 days, and at doses of 5, 10, 15 and 20 mg kg^βˆ’1^ day^

Deficiency of complex II of the mitochon
Deficiency of complex II of the mitochondrial respiratory chain in late-onset optic atrophy and ataxia
✍ Robert W. Taylor; Mark A. Birch-Machin; Jochen Schaefer; Louise Taylor; Raad Sha πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 941 KB

Defects of the mitochondrial respiratoiy chain are increasingly being recognized as an important cause of neurological disease in humans. In many of these patients, the biochemical defect results from an abnormality of the mitochondrial genome. Respiratory chain defects involving complex 11, which i

Evaluation of Methods for the Determinat
Evaluation of Methods for the Determination of Mitochondrial Respiratory Chain Enzyme Activities in Human Skeletal Muscle Samples
✍ Falk R. Wiedemann; Stefan Vielhaber; Rolf SchrΓΆder; Christian E. Elger; Wolfram πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 English βš– 70 KB

The quantification of mitochondrial enzyme activities in skeletal muscle samples of patients suspected of having mitochondrial myopathies is problematic. Therefore, we have evaluated different methods for the determination of activities cytochrome c oxidase and NADH:CoQ oxidoreductase in human skele

Studies on the mechanisms of neurulation
Studies on the mechanisms of neurulation in the chick: Morphometric analysis of the relationship between regional variations in cell shape and sites of motive force generation
✍ Nagele, Robert G. ;Lee, Hsin-Yi πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 English βš– 852 KB

Microfilaments, which are organized into bundles in the apical ends of neuroepithelial cells, are generally thought to play a major role in generating the driving forces for neural tube closure. Because of their proximity to the luminal surface, the contractile activity of these microfilament bundle