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Contribution of dead cells to the immunogenicity of an autologous, hapten-modified melanoma vaccine

โœ Scribed by David Berd


Book ID
117431291
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
55 KB
Volume
21
Category
Article
ISSN
0264-410X

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Background. The authors have demonstrated that immunization with melanoma whole-cell vaccine (MCV) augments T-cell responses to melanoma and that cytotoxic T-cells (CTL) recognize allogeneic melanoma-bearing shared HLA-A antigens. A preclinical model was developed to assess CTL activation in vitro u