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Contribution of claudin-5 to barrier properties in tight junctions of epithelial cells

✍ Scribed by Salah Amasheh; Thomas Schmidt; Michaela Mahn; Peter Florian; Joachim Mankertz; Shida Tavalali; Alfred H. Gitter; Jörg-Dieter Schulzke; Michael Fromm

Publisher: Springer-Verlag
Year: 2005
Tongue: English
Weight: 333 KB
Volume: 321
Category: Article
ISSN: 0302-766X
DOI: 10.1007/s00441-005-1101-0

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## Abstract Claudins are thought to be major components of tight junctions (TJs), and claudin‐5 and ‐12 are localized at TJs of the blood‐brain barrier (BBB). Claudin‐5‐deficient mice exhibit size‐selective (<800 Da) opening of the BBB. The purpose of this study was to clarify the expression levels