Contribution for Monitor, Drug Discovery Today - January 1999

• Book ID: 104438042
• Publisher: Elsevier Science
• Year: 1999
• Tongue: English
• Weight: 34 KB
• Volume: 1
• Category: Article
• ISSN: 1464-3383
• DOI: 10.1016/s1464-3383(04)80017-4

✦ Synopsis

Kinetic resolution by libraries

Ensuring that all chiral molecules are synthesised and tested as single enantiomers in biological systems is an essential requirement of modern drug discovery. Consequently, resolution of racemic materials, possibly using chiral HPLC, is often necessary to separate enantiomers. Combinatorial chemistry has recently been applied in the search for novel chiral selectors that will react enantiospecifically with racemic chemical compounds, specifically in this case, cyclic amino acid derivatives (M.