Contrasting patterns of newer histocompatibility determinants in patients with rheumatoid arthritis and systemic lupus erythematosus

✍ Scribed by Dr. Allan Gibofsky; Robert Winchester; John Hansen; Manuel Patarroyo; Bo Dupont; Steven Paget; Robert Lahita; James Halper; Marilena Fotino; Edmund Yunis; Henry G. Kunkel

• Publisher: John Wiley and Sons
• Year: 1978
• Tongue: English
• Weight: 445 KB
• Volume: 21
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780210920

✦ Synopsis

The Ia alloantigens as measures of different alleles of loci in the major histocompatibility complex were determined in patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). The Ia specificities of reagents used were defined by their pattern of reaction with lymphoblastoid lines derived from normal donors hornozygous for HLA-D determinants. The reagent specificities included those associated with a single Dw type as well as those reacting with a single specificity shared by several Dw types. Patients with RA had a marked elevation in the frequency of alloantigens detected by reagent sera that recognize various determinants shared by cell lines from HLA-Dw4, Dw7, or DwlO individuals (Ia 4-7- 10). The frequency of mixed lymphocyte culture alleles Dw4 and DwlO was found to be increased; however this elevation did not approach the higher frequency for the serologically determined antigens of the Ia 4-7-10 group.

In contrast, patients with SLE had an increased frequency of reactions with the reagent alloantisera defined by reactions with either HLA-Dw2 or Dw3 positive cell lines.