Contrasting expression of membrane metalloproteinases, MT1-MMP and MT3-MMP, suggests distinct functions in skeletal development
β Scribed by Maozhou Yang; Bingbing Zhang; Liang Zhang; Gary Gibson
- Publisher
- Springer-Verlag
- Year
- 2008
- Tongue
- English
- Weight
- 676 KB
- Volume
- 333
- Category
- Article
- ISSN
- 0302-766X
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## Abstract Membraneβtype metalloproteinaseβ1 (MT1βMMP) is a transmembrane metalloproteinase overexpressed in tumors, which plays a major role in the first step of proβMMPβ2 activation, leading to the generation of an intermediate 62 kDa species. The second step of MMPβ2 activation that yields to t
We have identified a novel membrane-type matrix metalloproteinase (MT-MMP) expressed on the cell surface and inducing activation of pro-gelatinase A in vitro. In this study, we further examined the possibility that MT-MMP is the activator of pro-gelatinase A in tumors as well as in vitro. Expression