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Contrasting effects of tetraethylammonium and 4-aminopyridine on the gastrointestinal function of mice

✍ Scribed by De-Li Dong; Qing-Hui Wang; Wei Chen; Jiao-Jie Fan; Jing-Wei Mu; Jia Ke; Bao-Feng Yang

Book ID
113585266
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
169 KB
Volume
509
Category
Article
ISSN
0014-2999

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The K+ channel blocker 4-aminopyridine (4-AP) causes epileptiform activity in in vitro preparations and is a potent convulsant in animals and man. In mice, 4-AP produces behavioral activation, clonic limb movements and wild running, followed by tonic hindlimb extension and death (ED97, 13.3 mg/kg, s