𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Contrast-enhanced MR imaging of diffuse and focal splenic disease with use of magnetic starch microspheres

✍ Scribed by Burkhard P. Kreft; Akihiro Tanimoto; Susan Leffler; J. Paul Finn; Audun N. Øksendal; David D. Stark

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
884 KB
Volume
4
Category
Article
ISSN
1053-1807

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The diagnostic value of magnetic starch microspheres (MSM), a new superparamagnetic contrast agent, was studied in experimental models of diffuse and focal splenic disease in rats by means of ex vivo relaxometry and in vivo magnetic resonance (MR) imaging. Owing to small differences in unenhanced T1 and T2 values between diffuse lymphoma and normal spleen, MR imaging failed to distinguish tumor‐bearing animals from control animals by signal‐to‐noise ratios (SNRs) obtained with T1‐ and T2‐weighted spin‐echo sequences. One hour after injection of 20 μmol/kg MSM, lymphomatous spleen showed significantly (P <.001) reduced enhancement relative to normal splenic tissue. As a result, animals with diffuse lymphoma (SNR: 10.3 ± 1.7) could be easily differentiated from control animals (SNR: 5.5 ± 0.6) on T2‐weighted (TR msec/TE msec = 2,000/45) images. In focal splenic disease, MSM produced normal enhancement of nontumorous splenic tissue, whereas relaxation times of tumors were not different before and after contrast agent injection. On T2‐weighted images (2,000/45), the tumor‐spleen contrast‐to‐noise ratio increased from (4.8 ± 1.6 to 21.8 ± 1.9 +354%), improving conspicuity of splenic tumors. The results show that MSM‐enhanced MR imaging improves the detection of diffuse and focal splenic disease.

📜 SIMILAR VOLUMES

Enhanced mass on contrast-enhanced breas
Enhanced mass on contrast-enhanced breast MR imaging: Lesion characterization using combination of dynamic contrast-enhanced and diffusion-weighted MR images
✍ Hidetake Yabuuchi; Yoshio Matsuo; Takashi Okafuji; Takeshi Kamitani; Hiroyasu So 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 282 KB

## Abstract ## Purpose To evaluate the diagnostic accuracy of a combination of dynamic contrast‐enhanced MR imaging (DCE‐MRI) and diffusion‐weighted MR imaging (DWI) in characterization of enhanced mass on breast MR imaging and to find the strongest discriminators between carcinoma and benignancy.

Contrast-enhanced FLAIR imaging in combi
Contrast-enhanced FLAIR imaging in combination with pre- and postcontrast magnetization transfer T1-weighted imaging: Usefulness in the evaluation of brain metastases
✍ Satoshi Terae; Daisuke Yoshida; Kohsuke Kudo; Khin Khin Tha; Masaharu Fujino; Ka 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 415 KB

## Abstract ## Purpose To assess whether the use of postcontrast fluid‐attenuated inversion recovery (FLAIR) imaging in combination with pre‐ and postcontrast magnetization transfer (MT) T1‐weighted imaging (T1WI) can increase diagnostic confidence in the evaluation of brain metastases. ## Materi

Assessment of tumor blood flow in breast
Assessment of tumor blood flow in breast tumors with T1-dynamic contrast-enhanced MR Imaging: Impact of dose reduction and the use of a prebolus technique on diagnostic efficacy
✍ Smitha Makkat; Robert Luypaert; Steven Sourbron; Tadeusz Stadnik; Johan De Mey 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 275 KB 👁 1 views

## Abstract ## Purpose: To prospectively evaluate whether dose reduction and the application of a prebolus technique can effectively alleviate signal saturation effects in T1 dynamic contrast enhanced (T1‐DCE) magnetic resonance imaging (MRI) data in breast tumors and lead to increased diagnostic

Improvement of image quality of non-inva
Improvement of image quality of non-invasive coronary artery imaging with magnetic resonance by the use of the intravascular contrast agent Clariscan™ (NC100150 injection) in patients with coronary artery disease
✍ Christoph Klein; Simon Schalla; Bernhard Schnackenburg; Axel Bornstedt; Volker H 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 803 KB

## Abstract ## Purpose To assess the feasibility of Clariscan™, an intravascular contrast agent, for free breathing, navigator assisted, high resolution, three‐dimensional‐magnetic resonance coronary angiography (MRCA) in patients, as extracellular contrast agents are unfavorable for the improveme