Contrast-enhanced MR angiography of the run-off vasculature: Intraindividual comparison of gadobenate dimeglumine with gadopentetate dimeglumine

✍ Scribed by Michael V. Knopp; Frederik L. Giesel; Hendrik von Tengg-Kobligk; Jannis Radeleff; Martin Requardt; Miles A. Kirchin; Hans-Rainer Hentrich

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 712 KB
• Volume: 17
• Category: Article
• ISSN: 1053-1807
• DOI: 10.1002/jmri.10313

✦ Synopsis

Abstract

Purpose

To compare intraindividually gadobenate dimeglumine (Gd‐BOPTA) with gadopentetate dimeglumine (Gd‐DTPA) for multi‐station MR Angiography of the run‐off vessels.

Materials and Methods

Twenty‐one randomized healthy volunteers received either Gd‐BOPTA or Gd‐DTPA as a first injection and then the other agent as a second injection after a minimum interval of 6 days. Each agent was administered at a dose of 0.1 mmol/kg bodyweight followed by a 25‐mL saline flush at a single constant flow rate of 0.8 mL/second. Images were acquired sequentially at the level of the pelvis, thigh, and calf using a fast three‐dimensional (3D) gradient echo sequence. Source, subtracted source, maximum intensity projection (MIP), and subtracted MIP image sets from each examination were evaluated quantitatively and qualitatively on a segmental basis involving nine vascular segments.

Results

Significantly (P < 0.05) higher signal‐to‐noise and contrast‐to‐noise ratios were noted for Gd‐BOPTA compared to Gd‐DTPA, with the more pronounced differences evident in the more distal vessels. Qualitative assessmentrevealed no differences in the abdominal vasculature, a preference for Gd‐BOPTA in the pelvic vasculature, and markedly better performance for Gd‐BOPTA in the femoral and tibial vasculature. Summation of individual diagnostic quality scores for each segment revealed a significantly (P = 0.0001) better performance for Gd‐BOPTA compared to Gd‐DTPA.

Conclusion

Greater vascular enhancement of the run‐off vasculature is obtained after Gd‐BOPTA, particularly in the smaller more distal vessels. Enhancement differences are not merely dose dependent, but may be due to different vascular enhancement characteristics of the agents. J. Magn. Reson. Imaging 2003;17:694–702. © 2003 Wiley‐Liss, Inc.