The influence of cell density and epidermal growth factor (EGF) on the expression and inducibility of cytochrome P450 (CYP) genes of the CYP3A and CYP1A families in adult human hepatocytes in primary culture has been evaluated. Only when cultured at subconfluence and in the presence of EGF did hepat
β¦ LIBER β¦
Contradistinctive growth responses of cultured rat intestinal epithelial cells to epidermal growth factor depending on cell population density
β Scribed by Jonathan Blay; Kenneth D. Brown
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 421 KB
- Volume
- 129
- Category
- Article
- ISSN
- 0021-9541
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## Abstract ## BACKGROUND. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFRβTKIs) have demonstrated clinical benefit in patients with nonsmall cell lung cancer (NSCLC), particularly those with tumors that have EGFRβTK domain mutations. Moreover, the EGFR and cyclooxygenase (COX)β2