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Contradistinction between doxorubicin and epirubicin: in-vivo metabolism, pharmacokinetics and toxicodynamics after single- and multiple-dosing in rats

✍ Scribed by Sandhya Ramanathan-Girish; Mehdi Boroujerdi

Book ID
111768709
Publisher
Pharmaceutical Press
Year
2001
Tongue
English
Weight
180 KB
Volume
53
Category
Article
ISSN
2042-7158

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The pharmacokinetics of a new serotonin 5-HT 2 antagonist, deramciclane, was studied. Single oral doses of 1, 3, 6 and 10 mg kg -1 and intravenous doses of 1, 3 and 6 mg kg -1 were administered in beagle dogs. Moreover, the steady state pharmacokinetics of 1, 3 and 6 mg kg -1 doses were studied. Der