Contractile response induced by a limonoid (humilinolide A) on spontaneous activity of isolated smooth muscle
✍ Scribed by Mercedes Perusquía; Ricardo Herńndez; María Adelina Jiménez; Rogelio Pereda-Miranda; Rachel Mata
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 88 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0951-418X
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✦ Synopsis
The in vitro effect of the limonoid humilinolide A, isolated from Swietenia humilis (Meliaceae), on spontaneous contractions of guinea-pig ileum, and uterus from oestrus, dioestrus, ovariectomized and oestrogen-primed rats was studied. Humilinolide A caused a concentration dependent and non-reversible excitatory effect on intestinal and uterine smooth muscle, distinguished as spasmogenic and uterotonic action respectively. However, the potency of this compound to induce contraction was different in the distinct preparations assayed: in ileal musculature of male guinea-pigs, as well as in uterine muscle of dioestrus and ovariectomized rats, a slight excitatory effect was observed; in contrast to an intense excitatory effect displayed in rat uterus with high oestrogen levels (oestrus and oestrogenized). These data suggest that the contractile response induced by humilinolide A could be mediated by oestrogens, probably by occupancy of some receptors in myometrial plasma membranes to induce uterotonic response, which may be oestrogen-dependent.