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Contractile activity of the N-acylated C-terminal part of substance P7–11in guinea pig trachea

✍ Scribed by Eric Tschirhart; Pascal Schmitta; Claude Bertrand; Michel Mayer; Sylviane Magneney; Yves Landry; Robert Michelot


Book ID
112275549
Publisher
Springer-Verlag
Year
1989
Tongue
English
Weight
501 KB
Volume
340
Category
Article
ISSN
0028-1298

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Backbone Cyclization of the C-terminal P
✍ Gal Bitan; Irena Zeltser; Gerardo Byk; David Halle; Yaffa Mashriki; Evgenia V. G 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 717 KB

Novel backbone-to-side chain and backbone-to-backbone cyclic analogues of substance P (SP) were prepared by solid-phase synthesis and screened for biological activity. An analogue containing a thioetherlactam ring between positions 9 and 11 showed an EC50 value of 20 nM toward the neurokinin 1 (NK-1