The large-scale solid-phase continuous flow synthesis of the bicyclic peptide MEN 10627, a new potent Neurokinin A receptor antagonist, is described using the Fmoc-polyamide method on both Macrosorb 125 and Macrosorb 250 resin. A new synthesizer designed in-house was realized by assembling Whitey va
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Continuous transport of solids using large pneumatic diaphragm pumps
β Scribed by Eckhard A Woelk
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 631 KB
- Volume
- 1996
- Category
- Article
- ISSN
- 0262-1762
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A preparative method for the preparation of large peptides is described. An advantageous theoretical weight of peptide/weight of starting resin ratio (tP w /R w ) of about 0.3 was successfully experimented. The esterification of the first amino acid was realized with a racemization of less than 1%.