Continuous production of tablet granulations in a fluidized bed I. Theory and design considerations
β Scribed by Morton W. Scott; Herbert A. Lieberman; Albert S. Rankell; Joseph V. Battista
- Publisher
- John Wiley and Sons
- Year
- 1964
- Tongue
- English
- Weight
- 644 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0022-3549
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π SIMILAR VOLUMES
The results of drying tests in a fluidized bed and a tray dryer are reported for typical tablet granulations. The data are analyzed to give estimates of total drying times, rates of dryin and overall heat transfer coefficients in each unit. It is concluded that fluidized f e d drying of tablet granu
mined from results with ejected tablets indicate that higher pressures are needed to fill the interparticulate void space than are in fact necessary. The effect of particle size is less clearly defined in the values of kl and kz but, again, there is the indication that the 75-104-pm. size fraction i
The continuous production of a hybrid antibiotic by a transformed strain of Streptomyces lividans TK21 in a three-phase fluidized bed is studied. Cell aggregates, known as pellets, are used as immobilized cell particles in the bioreactor. A methodology to prepare pellets of a suitable size and morph