Continuous intrathecal baclofen infusions induced a marked increase of the transcranially evoked silent period in a patient with generalized dystonia
✍ Scribed by Hartwig R. Siebner; Juergen Dressnandt; Carola Auer; Bastian Conrad
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 100 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0148-639X
No coin nor oath required. For personal study only.
✦ Synopsis
We observed a marked prolongation of the transcranially evoked silent period during continuous intrathecal administration of high doses of the gamma-aminobutyric acid (GABA) B receptor agonist baclofen in a patient with generalized dystonia. Size of motor evoked potentials and central conduction time remained unchanged during intrathecal baclofen administration. The selective prolongation of the silent period during highdose continuous intrathecal baclofen therapy supports the notion that GABA B -ergic intracortical interneurons play a part in the generation of the transcranially evoked silent period.